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KMID : 0370219970410040524
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Yakhak Hoeji
1997 Volume.41 No. 4 p.524 ~ p.529
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Cytotoxic Effects of Hydrolysable Tannins from Some Euphorbia Plants on the Human Tumor Cell Lines
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이승호/Lee SH
박지수/김소영/정시련/최상운/Park JS/Kim SY/Chung SR/Choi SU
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Abstract
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Seventy three hydrolysable tannins and related compounds were isolated from seven Euphorbia plants. Among them, 28 compounds including nine gallotannins, eleven ellagitan nins and eight related compounds were selected according to the structural similarity. Cytotoxicity of them on the human tumor cell lines including A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 were evaluated by the SRB method in vitro. 3,4,6-Tri-O-galloyl-D-glucose was shown to exhibit most potent cytotoxic effect(4.4mcg/ml < ED50 < 10.3mcg/ml)
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